Whilst loyal and affectionate with family, this is a slow maturing, extremely large breed and the associated chewing, jumping up and exuberant playing when young means that this is not an ideal breed for families with very small children or anyone who can be easily knocked over. This same caveat should apply to homes with much smaller dogs.
For those with the space, wipe clean home and large vehicle who want a larger dog with lower exercise requirements, the Neapolitan Mastiff can be an excellent member of the family.
While many dogs are traditionally thought of as being good with children, all dogs and children need to be taught to get on with and respect each other, and be safe together. Even so, dogs and young children should never be left alone together and adults should supervise all interactions between them.